Effect of Cholesterol and Curcumin on Ordering of DMPC Bilayers

Kotenkov Sergej Aleksandrovich; Gnezdilov Oleg Ivanovich; Khaliullina (Suleymanova) Aliya Vladimirovna; Gimatdinov Rustam Sayasovich; Filippov Andrei Vasilevich; Antzutkin Oleg N.

Effect of Cholesterol and Curcumin on Ordering of DMPC Bilayers

Kotenkov Sergej Aleksandrovich; Gnezdilov Oleg Ivanovich; Khaliullina (Suleymanova) Aliya Vladimirovna; Antzutkin Oleg N.; Gimatdinov Rustam Sayasovich; Filippov Andrei Vasilevich;

URI: https://dspace.kpfu.ru/xmlui/handle/net/147324

Дата: 2018

Аннотации:

In this work, we compared the effects of curcumin and cholesterol directly competing to insert into the DMPC lipid bilayer during bilayer formation from an initially non-ordered state. 2H and 14N nuclear magnetic resonance spectroscopy showed that curcumin is not embedded deep in the lipid bilayer and interacts mainly with the head group of the lipid. In a more complex system of DMPC/CHOL/CUR, curcumin amplifies the effect of cholesterol on the ordering of lipid acyl chains.

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