Effect of host liver cell proliferation on homing and phenotype of transplanted hepatic stellate cells after partial hepatectomy in rats

Kiyasov Andrey Pavlovich; Garanina Ekaterina Evgenevna; Rizvanov Albert Anatolevich; Shafigullina Aygul Kasyjmovna; Titova Angelina Andreevna; Zaikina Elvira Ildarovna; Mavlikeev Mikhail Olegovich; Gumerova Anisa Azatovna

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Effect of host liver cell proliferation on homing and phenotype of transplanted hepatic stellate cells after partial hepatectomy in rats

Shafigullina Aygul Kasyjmovna; Zaikina Elvira Ildarovna; Garanina Ekaterina Evgenevna; Titova Angelina Andreevna; Mavlikeev Mikhail Olegovich; Rizvanov Albert Anatolevich; Gumerova Anisa Azatovna; Kiyasov Andrey Pavlovich

URI: https://dspace.kpfu.ru/xmlui/handle/net/131558

Date: 2018

Abstract:

After PH first proliferate hepatocytes, then start nonparenchymal HSC and the last react cholangiocytes. Transplanted RFP+cells during the first week retained morphology and phenotype of hepatocytes, after 14 days they were RFP+/Desmin+ HSC, after 21 days found as RFP+/CK19+ cholangiocytes. Localization and phenotype of transplanted cells is strongly related with dynamic of host hepatic cell population proliferation.

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