Evidence Synthesis in Medicine Systematic Review & Meta-Analysis

Abstract

This educational and methodological handbook was created to guide readers through the complex and intellectually engaging process of conducting systematic reviews and meta-analyses. It presents a coherent and practice-oriented overview of contemporary standards in evidence-based medical research, combining methodological rigor with clarity and accessibility. The handbook presents general principles of systematic evidence synthesis and demonstrates their application through examples drawn from clinical medical research. It offers a step-by-step approach, from the formulation of a research question to the transparent reporting of results. Designed for independent self-study, the handbook targets medical students, clinicians, and researchers.