Study of the interaction of lovastatin with a transition group metal - gadolinium in solution using NMR spectroscopy

Abstract

Modification of biologically active compounds through the use of metal complexes is one of the promising directions in the development of drugs that must have certain previously known properties. Statins, being the most effective way to relieve atherosclerosis, have a wide range of side effects, such as myositis, increased production of liver enzymes. Studying the interaction of statins with transition group metals will help clarify ways to create a stable metal complex and subsequent studies on changes in pharmacokinetics. During the work, the type of interaction between lovastatin and gadolinium was determined as rapid exchange.