Photodynamic Therapy as Alternative Method of Treatment of Metastatic Ovarian Cancer with Many Recurrence: Case Report

Abstract

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Photodynamic therapy (PDT) is a minimally invasive therapeutic modality used for the treatment of a variety of cancers and benign diseases. The destruction of unwanted cells and tissues in PDT is achieved by the use of visible or near-infrared radiation to activate a light-absorbing compound (a photosensitizer), which, in the presence of molecular oxygen, leads to the production of singlet oxygen and other reactive oxygen species. Thus, the purpose of the report is to describe the clinical case of the effective use of intraoperative PDT as a method of treatment of a patient with metastatic cancer. Patient A, 59 years old, had ovarian cancer T3N1M0 stage III with peritoneal carcinomatosis. After intraoperative PDT (1.5 year) treatment, the progression of the process was not revealed by PET/CT. The results show that photodynamic therapy is one of the high efficiency methods of palliative treatment and it can be used for metastatic cancer. This technology should be included as a technique to the guidelines for the treatment of malignant tumors.