Abstract:
© 2020, Dynasty Publishing House. All rights reserved. Objective. To study the impact of radiation exposure on ovarian function in patients of reproductive age with uterine leiomyoma after uterine artery embolization. Patients and methods. 112 women of reproductive age between 26 and 40 years (on average 32.2 ± 1.7 years) with uterine leiomyoma were examined. The first group comprised 40 patients who were operated on according to a modified technique with the use of original equipment, the second group consisted of 38 patients, who underwent uterine artery embolization (UAE) via transradial access, третью – 34 patients, in whom UAE was performed by a standard method. Results. The use of a modified technique of catheterization of the uterine arteries and transradial access in UAE resulted in a decrease of fluoroscopy time and operative time 39% (р = 0.001). A significant (p < 0.01) decrease of radiation exposure in groups 1 and 2 was noted. Evaluation of ovarian reserve in patients has shown a significant decrease of the anti-Müllerian hormone (р < 0.05). Analysis of hormonal profile demonstrated that the average values of all parameters 6 months after UAE were within the normal range (FSH = 5.58 ± 0.4 IU/l, AMH = 3.2 ± 0.9 ng/ml, E2 = 51.35 ± 3.5 pg/ml). Six months after UAE a decrease of antral follicle count by 25% of the initial values was found in all patients. Conclusion. A decrease of ovarian reserve (based on lower AMH and AFC levels) in patients of reproductive should be attributed to the very fact of UAE. Also, more long-term research should be conducted for prognosis of UAE in patients of reproductive age.
