Synthesis of chiral melatonin salts of dithiophosphoric acids using monoterpenyl alcohol

Abstract

© 2020 Chemical Publishing Co.. All rights reserved. Dithiophosphoric acids in the terms of (S)-(–)-menthol, (1S)-endo-(–)-borneol,(1R)-endo-(+)-fenchyl alcohol and (1S,2S,3S,5R)-(+)-isopinocampheol react with melatonin to form chiral N-acetyl 5-methoxytryptammonium dithiophosphates. The interations proceed via increase in the coordination of indole nitrogen of melatonin. The antibacterial and antifungal activity of N-acetyl 5-methoxytryptammonium dithiophosphate containing (+)-fenchyl substituent was established.