N-Phosphorylated Pyrrolidines: An Overview of Synthetic Approaches

Abstract

© 2020 Georg Thieme Verlag. All rights reserved. Organophosphorus pyrrolidine derivatives possessing P-N bonds are a promising yet underexplored class of compounds. In this short review we overview the general approaches to these compounds described so far, with a special emphasis on their asymmetric synthesis. 1 Introduction 2 Synthesis of Pyrrolidine-Based P(III) Derivatives 3 Synthesis of Pyrrolidine-Based P(V) Derivatives 3.1 Phosphorylation of Pyrrolidines with P(V) Acid Chlorides 3.2 Phosphorylation of Pyrrolidines with P(V) Acid Esters 3.3 Syntheses via the Atherton-Todd Reaction 3.4 Oxidation of Pyrrolidine-Based P(III) Derivatives 4 Syntheses of N-Phosphorylpyrrolidines from Acyclic Precursors 5 Conclusions.