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Aureolic Acid Group of Agents as Potential Antituberculosis Drugs

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dc.contributor Казанский федеральный университет
dc.contributor.author Bespyatykh Yuliya Andreevna
dc.contributor.author Bespiatykh Dmitriy Andreevich
dc.contributor.author Malakhova Maja
dc.contributor.author Klimina Ksenia
dc.contributor.author Bespyatykh Andrej Vasilevich
dc.contributor.author Varizhuk Anna
dc.contributor.author Tevyashova Anna
dc.contributor.author Nikolenko Tatiana
dc.contributor.author Pozmogova Galina
dc.contributor.author Ilina Elena
dc.contributor.author Shitikov Egor
dc.date.accessioned 2020-10-26T10:42:19Z
dc.date.available 2020-10-26T10:42:19Z
dc.date.issued 2020
dc.identifier.citation Bespyatykh J., Bespiatykh D., Malakhova M., Klimina K., Bespyatykh A., Varizhuk A., Tevyashova A., Nikolenko T., Pozmogova G., Ilina E., Shitikov E. Aureolic Acid Group of Agents as Potential Antituberculosis Drugs //Antibiotics. - 2020. - Т. 9. - №. 10. - Р. 715-730.
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/159521
dc.description.abstract Mycobacterium tuberculosis is one of the most dangerous pathogens. Bacterial resistance to antituberculosis drugs grows each year, but searching for new drugs is a long process. Testing for available drugs to find active against mycobacteria may be a good alternative. In this work, antibiotics of the aureolic acid group were tested on a model organism Mycobacterium smegmatis. We presumed that antibiotics of this group may be potential G4 ligands. However, this was not confirmed in our analyses. We determined the antimicrobial activity of these drugs and revealed morphological changes in the cell structure upon treatment. Transcriptomic analysis documented increased expression of MSMEG_3743/soj and MSMEG_4228/ftsW, involved in cell division. Therefore, drugs may affect cell division, possibly disrupting the function of the Z-ring and the formation of a septum. Additionally, a decrease in the transcription level of several indispensable genes, such as nitrate reductase subunits (MSMEG_5137/narI and MSMEG_5139/narX) and MSMEG_3205/hisD was shown. We concluded that the mechanism of action of aureolic acid and its related compounds may be similar to that bedaquiline and disturb the NAD+/NADH balance in the cell. All of this allowed us to conclude that aureolic acid derivatives can be considered as potential antituberculosis drugs.
dc.language.iso en
dc.relation.ispartofseries Antibiotics
dc.rights открытый доступ
dc.subject Mycobacterium smegmatis; TB treatment; Olivomycin; Mycobacterium tuberculosis; transcriptomic
dc.title Aureolic Acid Group of Agents as Potential Antituberculosis Drugs
dc.type Article
dc.contributor.org Институт фундаментальной медицины и биологии
dc.description.pages 715-730
dc.relation.ispartofseries-issue 10
dc.relation.ispartofseries-volume 9
dc.pub-id 240150
dc.identifier.doi 10.3390/antibiotics9100715

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