Participation of NPY<inf>1</inf>-receptors in developing heart regulation

Abstract

© 2019 Plant Archives. All rights reserved. In the present work, they studied the effect of the selective NPY1 agonist of Leu (31), Pro (34) -NPY receptors of different concentrations on the myocardial contractility of neonatal and adult rats. During analysis of the myocardial strip isometric contraction, they found that the agonist causes a dose-dependent changes of the myocardial strip contraction strength. Leu31, Pro34NPY in the concentration range of 10-7-10-5 M does not cause significant changes in the isometric contraction of the myocardial strips in the atria and ventricles among 7-day-old animals. Among 21-day-old animals, Leu31, Pro34NPY, at the concentration of 10-6 M, and the agonist (10-7 M) increases the force of contraction in the myocardium among 100-day-old animals.