Three modalities of synaptic release of neuromediators: Fast synchronous, multivesicular, and asynchronous. similarities and differences in mechanisms

Abstract

© 2019 Maik Nauka-Interperiodica Publishing. All rights reserved. Synapses in the central nervous system have several modalities of neuromediator release: Phasic (synchronous), asynchronous, and multivesicular. Here, we summarized results of recent studies that demonstrate involvement of different calcium sensors in triggering of synchronous and asynchronous release of neuromediator. In addition, we reviewed possible sources of presynaptic Ca2+ that trigger asynchronous release as well as possible mechanisms of multivesicular release.