Effect of Neuropeptide Y on Action Potential of Working Right Atrial Cardiomyocytes in Early Postnatal Ontogeny

Abstract

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. The effects of neuropeptide Y (10—9-10—6 M) on electrical activity of right atrial cardiomyocytes of rats aging 7, 21, and 100 days were examined in vitro. Neuropeptide Y affected the amplitude-temporal parameters of the action potential in these cells. It decreased the duration of repolarization phase in 7-day-old rats in concentrations of 10—8 and 10—7 M, in 21-day-old rats at 10—8 and 10—6 M, and in 100-day-old at 10—6 M. The data indicate elevation of total membrane potassium current under the action of neuropeptide Y.