Effect of Stimulation of α<inf>2</inf>-Adrenergic Receptors on Action Potential of Working Cardiomyocytes in Rat Atrium

Abstract

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. The study examined the effect of clonidine hydrochloride (10—9-10—5 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α2-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of 10—5 М.