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NMR screening and studies of target-ligand interactions

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dc.contributor Казанский федеральный университет
dc.contributor.author Польшаков Владимир Иванович
dc.contributor.author Батуев Евгений Андреевич
dc.contributor.author Манцызов Алексей Борисович
dc.date.accessioned 2019-02-12T12:08:12Z
dc.date.available 2019-02-12T12:08:12Z
dc.date.issued 2019
dc.identifier.citation Polshakov V.I. (2019). NMR screening and studies of target-ligand interactions / V. I. Polshakov, E.A. Batuev, A.B. Mantsyzov // Russian Chemical Reviews, 88(1). - PP. 59-98.
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149808
dc.description.abstract Nuclear magnetic resonance (NMR) spectroscopy is one of the leading biophysical methods used in the search for and design of physiologically active compounds considered as potential drugs. The review concerns modern NMR techniques used to study the binding of low-molecular-mass compounds to biomacromolecular targets. The most promising methods of NMR screening and strategies for rational lead design are discussed. They were used to design drugs that have been approved for the use in medical practice or are in the final stages of clinical trials. Examples are given of the application of the fragment-based drug design and NMR screening techniques to the design of novel drugs.
dc.language.iso ru
dc.relation.ispartofseries RUSSIAN CHEMICAL REVIEWS
dc.rights открытый доступ
dc.subject NMR spectroscopy
dc.subject protein-ligand interaction
dc.subject NMR screening
dc.subject biological targets
dc.subject physiologically active compounds
dc.subject rational drug design
dc.subject fragment-based lead design
dc.subject structure-activity relationship
dc.subject.other Биология
dc.subject.other Медицина и здравоохранение
dc.subject.other Химия
dc.title NMR screening and studies of target-ligand interactions
dc.type Article
dc.contributor.org Институт фундаментальной медицины и биологии
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 88
dc.pub-id 195615

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