Coprecipitation Method of Synthesis, Characterization, and Cytotoxicity of Pr³⁺:LaF<inf>3</inf>(C<inf>Pr</inf>= 3, 7, 12, 20, 30%) Nanoparticles

Abstract

© 2018 Maksim S. Pudovkin et al. The Pr3+:LaF3(CPr= 3, 7, 12, 20, 30%) nanoparticles were characterized by means of high-resolution transmission electron microscopy, X-ray diffraction, optical spectroscopy, energy dispersive X-ray spectroscopy, dynamic light scattering, and MTT assay. It was revealed that the average diameter of all the NPs is around 14-18 nm. The hydrodynamic radius of the Pr3+:LaF3(CPr= 7%) nanoparticles strongly depends on the medium. It was revealed that hydrodynamic radii of the Pr3+:LaF3(CPr= 7%) nanoparticles in water, DMEM, and RPMI-1640 biological mediums were 18 ± 5, 41 ± 6, and 186 ± 8 nm, respectively. The Pr3+:LaF3(CPr= 7%) nanoparticles were nontoxic at micromolar concentrations toward COLO-320 cell line. The lifetime curves were fitted biexponentially, and for the Pr3+:LaF3(CPr= 7%) NPs, the luminescence lifetimes of Pr3+ions were 480 ± 2 and 53 ± 5 nanosec.