First Total Synthesis of 7-Isovaleryloxy-8-methoxygirinimbine

Abstract

© Georg Thieme Verlag Stuttgart New York Synthesis. We describe the first total synthesis of the pyrano[3,2- a ]carbazole alkaloid 7-isovaleryloxy-8-methoxygirinimbine, using a palladium(II)-catalyzed double C-H-bond activation for construction of the carbazole framework and a phenylboronic acid catalyzed annulation of the pyran ring as key steps.