Arbidol: A quarter-century after. Past, present and future of the original Russian antiviral

Abstract

© 2018 Uspekhi Khimii, Russian Academy of Sciences and Turpion Ltd. The present review is concerned with the synthesis and structure-activity relationship studies of Arbidol and its structural analogues. The latter are roughly divided into several unequal parts: indole- and benzofuran-based compounds, benzimidazole and imidazopyridine bioisosteres and ring-expanded quinoline derivatives. Much attention is focused on various types of antiviral activity of the above-mentioned Arbidol congeners, as well as of the parent compound itself. Features of Arbidol synthesis and metabolic changes are also discussed.