Antibiotic resistance of staphylococcus aureus and pseudomonas aeruginosa in the model of cystic fibrosis as a chronic disease of the bronchopulmonary system

Abstract

© 2018, Pediatria Ltd.. All rights reserved. The course and prognosis of cystic fibrosis (CF) in many ways depend on the degree of bronchopulmonary system lesion. Important role in the development of chronic inflammation in the bronchopulmonary system belongs to conditionally pathogenic microorganisms. Rational antibiotic therapy (ABT) allows to restrain the natural course of the disease. How ever, wide spread use of antibiotics (AB) creates problems of microorganisms' resistance. The article reviews the literature on antibacterial resistance (ABR) development mechanisms of Staphylococcus aureus and Pseudomonas aeruginosa, which most often colonize the respiratory tract in CF. Staphylococcus aureus and Pseudomonas aeruginosa ABR realizes by the mechanisms of natural and acquired resistance. The acquired resistance of bacteria develops as a result of natural selection through random mutations and/or through the action of antibacterial drugs. Microorganisms carry genetic information of resistance to antibiotics by horizontal gene transfer, which threatens the spread of multidrug resistant bacteria strains. Rational ABT is a key mechanism for restraining the development of bacteria antibiotic resistance.