Effect of Neuropeptide Y on Action Potential Generation in Working Cardiomyocytes of the Right Atrium in Rat Heart

Abstract

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. We studied the effect of neuropeptide Y in concentrations of 10—8-10—6 M on electrical activity of adult rat right atrial cardiomyocytes with preserved spontaneous activity. Neuropeptide Y was found to modulate the amplitude-time parameters of action potential: in concentrations of 10—7 and 10—6 M it reduced the membrane potential, increased the amplitude of action potential and duration of the repolarization phase, and reduced the frequency of action potential generation. In concentration of 10—6 M, neuropeptide Y produced stronger effect on the analyzed parameters, while in concentration of 10—8 M it produced no significant changes.