p-tert-butyl thiacalix[4]arene derivatives functionalized in the lower rim with bis(3-aminopropyl)amine: Synthesis and interaction with DNA

Abstract

© ISUCT Publishing. New tetrasubstituted derivatives of thiacalix[4]arene functionalized with bis(3-aminopropyl)amide fragments at the lower rim in the cone and 1,3-alternate conformations have been synthesized. It was demonstrated that the synthesized thiacalix[4]arenes derivatives interact with DNA resulting in a shift in absorption maxima to 257 nm with clear isosbestic point at 300 nm.