Endogenous secretion of vascular endothelial growth factor by multipotent mesenchymal stromal cells derived from human third molar dental follicles

Abstract

Human stem cells secretome is currently a very hot area of research. We report that multipotent mesenchymal stromal cells isolated from human third molar dental follicles (MMSC-TMDF), are able to secrete high levels of vascular endothelial growth factor (VEGF) when cultured in vitro. Due to the fact that VEGF is a well known angiogenic and neuroprotective factor, the use of MMSC-TMDF is promising for the development of stem cell therapy of various degenerative human diseases.