A calorimetric study of the formation of phenacetin solid dispersions with PEG-1400 and pluronic F127

Abstract

The formation of solid dispersions is one of the methods of drug hydrophilization. The method of low-temperature differential scanning calorimetry showed the possibility to obtain phenacetin solid dispersions with polyethylene glycol and Pluronic F127. The method of low-temperature differential scanning calorimetry proved that when the polymer/phenacetin ratio is 10:1, the crystalline phase of the drug is not fixed, while when the ratio is 1:1 the pharmacological component exhibits the properties of a separate phase and does not form a solid dispersion. Phenacetin does not exhibit plastifying action and does not change the thermophysical properties of polymer phase that can facilitate an easy release of the drug from the composite. © IDOSI Publications, 2013.