Synthesis of novel mono- and bisaminophosphoryl compounds and their membrane transport properties for acidic substrates

Abstract

Some novel aminophosphoryl compounds were synthesized by the Kabachnik-Fields reaction. Their membrane transport properties for mono-and polyfunctional carboxylic acids with different number of functional groups were studied to establish that the transport rate of acidic substrates through liquid impregnated membranes increases in going from mono-to diphosphoryl carriers. Additional hydrophilic groups in the substrate molecule, too, affect transport efficiency. © 2008 MAIK Nauka.