Synthesis of α-aminophosphine oxides with chiral phosphorus and carbon atoms

Abstract

Lipophilic α-aminophosphine oxides are good extractants for liquid and membrane extraction. Optically active α-aminophosphine oxides, containing chiral centers in their structure, can provide selective means for transfer of stereoisomers through supported liquid membranes. We have developed a method for synthesis of such carrier compounds based on a three-component Kabachnik-Fields reaction. Copyright © Taylor & Francis Group, LLC.