Increasing permeability of phospholipid bilayer membranes to alanine with synthetic α-aminophosphonate carriers

Abstract

A series of aminophosphonates was synthesized, and their ability to carry alanine, a model hydrophilic molecule, across phospholipid bilayer membranes was evaluated. Aminophosphonates facilitate the membrane transport at moderate rates, which make them a suitable platform for the design of carriers for continuous drug release devices. © 2008 Elsevier Ltd. All rights reserved.