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Endo-α-1,4-polygalactosaminidases and their homologs: Structure and evolution

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dc.contributor.author Naumoff D.
dc.contributor.author Stepuschenko O.
dc.date.accessioned 2018-09-18T20:06:14Z
dc.date.available 2018-09-18T20:06:14Z
dc.date.issued 2011
dc.identifier.issn 0026-8933
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/136531
dc.description.abstract Endo-α-1,4-polygalactosaminidase is a rare enzyme. Its catalytic domain belongs to the GH114 family of glycoside hydrolases. It is shown by phylogenetic analysis that the evolution of the corresponding genes involved duplications, elimination, and horizontal transfer. The domain and secondary structures of endo-α-1,4-polygalactosaminidases are discussed. A hypothesis is put forward as to the structure of the active center of the enzyme. Iterative screening of a protein database reveals evolutionary relationships of the GH114 family with the GH13, GH18, GH20, GH27, GH29, GH31, GH35, GH36, and GH66 families of glycoside hydrolases and with the COG1306, COG1649, COG2342, GHL3, and GHL4 families of proteins with unknown enzymatic functions. Unclassified homologs are grouped into 13 new families of hypothetical glycoside hydrolases: GHL5-GHL15, GH36J, and GH36K. © 2011 Pleiades Publishing, Ltd.
dc.relation.ispartofseries Molecular Biology
dc.subject CAZy
dc.subject COG2342 family
dc.subject endo-α-1,4-polygalactosaminidase
dc.subject gene annotation
dc.subject GH114 family
dc.subject GH36 family
dc.subject GHL families
dc.subject glycoside hydrolase
dc.subject hierarchical protein classification
dc.subject horizontal transfer
dc.subject multiple sequence alignment
dc.subject new protein families
dc.subject protein evolution
dc.subject protein phylogenetic tree
dc.subject PSI Protein Classifier
dc.subject PSI-BLAST
dc.subject search for homologs
dc.subject TIM-barrel fold
dc.title Endo-α-1,4-polygalactosaminidases and their homologs: Structure and evolution
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 45
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 647
dc.source.id SCOPUS00268933-2011-45-4-SID79961164094


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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