Effect of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiovascular System in Rats

Abstract

© 2015, Springer Science+Business Media New York. Selective blockade of various α2-adrenoceptors exerts various effects on the cardiovascular system in rats. Blockade of α2A/D-adrenoceptors in experimental animals decelerates and then accelerates HR. Blockade of α2B-adrenoceptors produces a negative chronotropic effect; blockade of α2C-adrenoceptors has a positive chronotropic effect. Administration of selective blockers of α2A/D- and α2B-adrenoceptors causes hypotension, while selective blockade of α2C-adrenoceptors increases BP.