Inotropic effect of dopamine on rat heart during postnatal ontogeny

Abstract

We studied the effect of dopamine in concentrations of 10-9, 10-8, 10-7, 10-6, and 10-5 M on contraction strength of isolated myocardial strips from the right atrium and right ventricle of rats aging 21, 42, 56, and 100 days. Dopamine in a concentration of 10-9 M had a positive inotropic effect in rats of various ages. Increasing the concentration of dopamine to 10-7- 10-5 M was accompanied by a negative inotropic effect on the heart. © 2013 Springer Science+Business Media New York.