Galvanostatic coulometric determination of salicylic acid and some of its derivatives using electrogenerated halogens

Abstract

Reactions of electrogenerated bromine and chlorine with salicylic acid and some of its derivatives were studied. Procedures for the galvanostatic coulometric determination of 2.4 to 19.2 μg/mL of salicylic, acetylsalicylic, para-aminosalicylic acids and mesalazine in model solutions and medicinal preparations with electrogenerated halogens were developed (RSD varied from 1 to 5%). The end-point of coulometric titration was determined amperometrically with two polarized platinum electrodes.