Modification of Bacillus intermedius ribonuclease by urea derivatives

Abstract

The results of the 'Bacillus intermedius' RNAase modification by urea derivatives are presented. The modifiers synthesized for that purpose were the following: N-(4-chlorbenzoyl)-N'-benzolsulfonyl urea (M 1) and N-(4-chlorbenzoyl)carbomoyl-ε-aminocapronic acid (M 2). It was shown that RNAase modified by M 2 stimulated the cell general metabolism by the test of the cell absorption of neutral red and had a more marked ability to disrupt RNA of the cell plasmatic membranes in comparison to that of the native enzyme.