Abstract:
Blockade of α1-adrenoreceptors with prazosin produces bradycardia. The degree of this bradycardia in rats depends on age. In adult (20-week-old) rats bradycardia is pronounced, in 3-week-old rats it is insignificant, and in 1-week-old rats bradycardia does not develop. Prazosin moderates bradycardia induced by vagal stimulation in rats of different age.