Derivatives of phosphorus acids and α-chloroallyl alcohol - Communication 2. Synthesis of mixed α-chloroallyl esters of phosphoric acid and some of their biological properties

Abstract

1. A series of derivatives of phosphorus acids and α-chloroallyl alcohol was obtained. 2. Increasing the length of the hydrocarbon radical attached to the phosphorus atom from C1 to C6 leads to a sharp increase in the selectivity of the action of the compounds toward Trichophyton gypseum and Epidermophyton Kaufmann-Wolf. A further increase in the length of the radical decreases the anti-fungal activity of the compounds. 3. It was established that di-n-amyl α-chloroallyl phosphate has the highest selectivity index of action toward dermatophytes. © 1972 Consultants Bureau.