Properties of deoxyribonuclease of rat liver nuclei and changes in its activity during induced synthesis of nucleic acids

Abstract

DNAase from the proteins of chromatin obtained from rat livers preferentially hydrolyzes denatured DNA on the 3' phosphodiester bonds, forming oligonucleotides consisting of 6 to 8 monomers. The DNAase is not specific with respect to the bases. During the induced synthesis of DNA and RNA in rat liver cells a decrease was noted in the DNAase activity of the chromatin proteins.