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Browsing by Author "Vyshtakalyuk A."

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Comparative Evaluation of Hepatoprotective Activity of Xymedon Preparation Derivatives with Ascorbic Acid and Methionine

Vyshtakalyuk A.; Parfenov A.; Gumarova L.; Nazarov N.; Zobov V.; Galyametdinova I.; Semenov V. (2017)

© 2017, Springer Science+Business Media, LLC. The main objective of this work was a comparative evaluation of hepatoprotective activity of pyrimidine derivative of the active compound of Xymedon (1-(ß-oxyethyl)-4.6-dimet ...
Efficiency of new pyrimidine derivativs influence on physical working capacity of rats in the test 'swimming to failure'

Zobov V.; Nazarov N.; Vyshtakalyuk A.; Galyametdinova I.; Semenov V.; Reznik V. (2015)

© Northern State Medical University. There have been studied effects of xymedon and six new pyrimidine derivatives, that are close and distant analogs of xymedon, on rats' working capacity in the test "swimming to failure". ...
Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride

Vyshtakalyuk A.; Nazarov N.; Zobov V.; Abdulkhakov S.; Minnekhanova O.; Semenov V.; Galyametdinova I.; Cherepnev G.; Reznik V. (2017)

© 2017, Springer Science+Business Media New York.Hepatoprotective properties of a new pyrimidine derivative — L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were ...
Hepatoprotective Effect of Inonotus obliquus Melanins: In Vitro and In Vivo Studies

Parfenov A.; Vyshtakalyuk A.; Sysoeva M.; Sysoeva E.; Latipova A.; Gumarova L.; Zobov V. (2019)

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. The purpose of this study is to identify hepatoprotective properties of melanins from aqueous extracts of Inonotus obliquus distinguished by microwave ...
Research of the act-protective properties of xymedon and its new analogs

Nazarov N.; Zobov V.; Vyshtakalyuk A.; Reznik V. (2015)

This paper deals with the effects of the medicinal agent xymedon and its six new two-fragment analogs containing fragments of xymedon and biogenic acids, in the stimulation of rats' physical performance in the test of ...
Study of hepatoprotective effects of xymedon

Vyshtakalyuk A.; Nazarov N.; Zueva I.; Lantsova A.; Minnekhanova O.; Busygin D.; Porfiryev A.; Evtyugin V.; Reznik V.; Zobov V. (2013)

Xymedon (1-(β-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine), a regeneratory and wound-healing drug, exhibited hepatoprotective activity in laboratory animals with experimental toxic hepatitis. Oral drug reduced the ...
Synthesis and primary evaluation of the hepatoprotective properties of novel pyrimidine derivatives

Vyshtakalyuk A.; Semenov V.; Zobov V.; Galyametdinova I.; Gumarova L.; Parfenov A.; Nazarov N.; Lenina O.; Kondrashova S.; Latypov S.; Cherepnev G.; Shashyn M.; Reznic V. (2017)

© 2017, Pleiades Publishing, Ltd. Based on the active ingredient of the drug Ximedon (1,2-dihydro-4,6-dimethyl-1-N-(2-hydroxyethyl)pyrimidone-2, referred below to as pyrimidine (I), novel derivatives containing biogenic ...
Synthesis, Physicochemical Properties and Anti-Fatigue Effect of Magnesium, Zinc and Chromium Polygalacturonate Based Composition

Milyukov V.; Khabibullina A.; Arkhipova D.; Mironov V.; Khamatgalimov A.; Ryzhkina I.; Murtazina L.; Mironova L.; Vyshtakalyuk A.; Nemtarev A.; Nazarov N.; Kholin K.; Nizameev I.; Minzanova S. (2019)

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The present study is focused on the development of a composition based on three pectin metal complexes (NaMg-PG, NaZn-PG and NaCr-PG) at a mass ratio 7:0.3:0.001. It was ...
The influence of the L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one on the regeneration of Girardia tigrina planarians

Nazarov N.; Vyshtakalyuk A.; Zobov V.; Semenov V. (2021)

The effect of the L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one on blastema regeneration in Girardia tigrina planarians was investigated. It was established that the preparation has low toxicity ...
The study of chronic toxicity of L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one

Nazarov N.; Vyshtakalyuk A.; Zobov V.; Semenov V. (2021)

The main purpose of the work is to study toxicological effect of new pyrimidine derivative, saltlike conjugate of the drug Xymedon with L-ascorbic acid. As a result, it was shown that when intravenous injection of L- ...
The study of the toxicity of the L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one on Chlorella vulgaris

Nazarov N.; Vyshtakalyuk A.; Zobov V.; Semenov V. (2021)

A laboratory culture of Chlorella was used to evaluate the toxicity of L-ascorbate 1-(2-hydroxyethyl)- 4,6-dimethyl-1,2-dihydropyrimidine-2-one synthesized on the basis of the drug Xymedon. Acute toxic effect by inhibiting ...

Now showing items 1-11 of 11

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Browsing by Author "Vyshtakalyuk A."

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