Comparative Evaluation of Hepatoprotective Activity of Xymedon Preparation Derivatives with Ascorbic Acid and Methionine

Abstract

© 2017, Springer Science+Business Media, LLC. The main objective of this work was a comparative evaluation of hepatoprotective activity of pyrimidine derivative of the active compound of Xymedon (1-(ß-oxyethyl)-4.6-dimethyl-1.2-dihydro-2-oxopirimidon) and its derivatives with methionine and ascorbic acid. The experiment was conducted on nonlinear white rats of both sexes based on the model of toxic damage inflicted on liver by CCl 4 with prophylactic scheme. The compounds were injected at doses of 1/500 LD 50 (13 mg/kg for Xymedon and 11 mg/kg for its derivatives with ascorbic acid and methionine). The study showed that, out of the three compounds considered, the Xymedon derivative with ascorbic acid had the most prominent hepatoprotective properties, as, given the CCl 4 poisoning, it caused the greatest decrease of liver damage area (by a factor of 3.25 over control) and change of the largest number of biochemical markers towards normalization. The Xymedon derivative with methionine had less prominent hepatoprotective properties than both the derivative with ascorbic acid and Xymedon itself.