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Browsing by Author "Masgutov R."

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Adipose-derived mesenchymal stem cells applied in fibrin glue stimulate peripheral nerve regeneration

Masgutov R.; Masgutova G.; Mullakhmetova A.; Zhuravleva M.; Shulman A.; Rogozhin A.; Syromiatnikova V.; Andreeva D.; Zeinalova A.; Idrisova K.; Allegrucci C.; Kiyasov A.; Rizvanov A. (2019)

© 2019 Masgutov, Masgutova, Mullakhmetova, Zhuravleva, Shulman, Rogozhin, Syromiatnikova, Andreeva, Zeinalova, Idrisova, Allegrucci, Kiyasov and Rizvanov. Mesenchymal stem cells (MSCs) hold a great promise for cell therapy. ...
Analyzing the Effectiveness of Adipose Tissue Stem Cell and Microvesicle Therapy in Premature Skin Aging Caused by Chronic Exposure to Ultraviolet Radiation

Syromiatnikova V.; Idrisova K.; Masgutova G.; Gomzikova M.; Kabwe E.; Bek J.; Andreeva D.; Masgutov R.; Mullakhmetova A.; James V.; Rizvanov A. (2020)

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Adipose-derived mesenchymal stem cells (ADSCs) and microvesicles (MVs) isolated from ADSCs are promising therapeutic agents for various pathological ...
Angiogenesis and nerve regeneration induced by local administration of plasmid pBud-coVEGF165-coFGF2 into the intact rat sciatic nerve

Masgutov R.; Zeinalova A.; Bogov A.; Masgutova G.; Salafutdinov I.; Garanina E.; Syromiatnikova V.; Idrisova K.; Mullakhmetova A.; Andreeva D.; Mukhametova L.; Kadyrov A.; Pankov I.; Rizvanov A. (2021)

Vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) are well-known growth factors involved in the regeneration of various tissues and organs, including peripheral nerve system. In the present ...
Application of Allogenic Adipose-Derived Multipotent Mesenchymal Stromal Cells from Cat for Tibial Bone Pseudoarthrosis Therapy (Case Report)

Zakirova E.; Valeeva A.; Masgutov R.; Naumenko E.; Rizvanov A. (2017)

© 2016, Springer Science+Business Media New York.A clinical case reported here demonstrates the possibility of using the multipotent mesenchymal stromal cells obtained from the donor animal to stimulate the process of bone ...
Combined treatment of throphic ulcer of the heel using vacuum therapy with direct gene therapy: Case report

Mullin R.; Masgutov R.; Salafutdinov I.; Rizvanov A.; Bogov A. (2013)

In this article we describe a clinical case of successful treatment of neurotrophic ulcers of heel region using classical surgical techniques such as debridement and autodermoplastics combined with vacuum therapy and ...
Comparative Analysis of the Effect of Gene-Activated Grafts Carrying a PBUD-VEGF165A-BMP2 Plasmid on Bone Regeneration in a Rat Femur Defect Model

Zhuravleva M.; Khaliullin M.; Masgutov R.; Bozo I.; Rizvanov A.; Deev R. (2019)

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Delayed union and non-union are widespread complications of bone fracture healing which are worse in cases of concomitant chronic diseases (diabetes ...
Genetic modification of adipose derived stem cells with recombinant plasmid DNA pBud-VEGF-FGF2 results in increased of IL-8 and MCP-1 secretion

Solovyeva V.; Salafutdinov I.; Tazetdinova L.; Khaiboullina S.; Masgutov R.; Rizvanov A. (2014)

Bacterial plasmid DNA is often used in gene therapy application as a vector for delivering recombinant genes into eukaryotic cells. In this work we study effect of plasmid DNA encoding pro-angiogenic growth factors VEGF ...
Human adipose-derived stem cells stimulate neuroregeneration

Masgutov R.; Masgutova G.; Zhuravleva M.; Salafutdinov I.; Mukhametshina R.; Mukhamedshina Y.; Lima L.; Reis H.; Kiyasov A.; Palotás A.; Rizvanov A. (2015)

© 2015 Springer-Verlag Italia Traumatic brain injuries and degenerative neurological disorders such as Alzheimer’s dementia, Parkinson’s disease, amyotrophic lateral sclerosis and many others are characterized by loss of ...
Human adipose-derived stem cells stimulate neuroregeneration

Masgutov R.; Masgutova G.; Zhuravleva M.; Salafutdinov I.; Mukhametshina R.; Mukhamedshina Y.; Lima L.; Reis H.; Kiyasov A.; Palotás A.; Rizvanov A. (2016)

© 2015, Springer-Verlag Italia.Traumatic brain injuries and degenerative neurological disorders such as Alzheimer’s dementia, Parkinson’s disease, amyotrophic lateral sclerosis and many others are characterized by loss of ...
Mesenchymal stem cell therapy for spinal cord contusion: A comparative study on small and large animal models

Mukhamedshina Y.; Shulman I.; Ogurcov S.; Kostennikov A.; Zakirova E.; Akhmetzyanova E.; Rogozhin A.; Masgutova G.; James V.; Masgutov R.; Lavrov I.; Rizvanov A. (2019)

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Here, we provide a first comparative study of the therapeutic potential of allogeneic mesenchymal stem cells derived from bone marrow (BM-MSCs), adipose tissue ...
Multiplex Analysis of the Activation of the Immune System after Transection of the Rat’s Sciatic Nerve

Masgutova G.; Martynova E.; Masgutov R.; Mukhametova L.; Mullakhmetova A.; Kadyrova G.; Khaiboullina S.; Rizvanov A. (2017)

© 2016, Springer Science+Business Media New York.In this study, using the model of sciatic nerve transection in rats, the cytokine profile of peripheral blood serum and rat sciatic nerve fragments was measured 3, 7 and ...
Reaction of oligoglia to spinal cord injury in rats and transplantation of human olfactory ensheathing cells

Masgutova G.; Savchenko E.; Viktorov I.; Masgutov R.; Chelyshev Y. (2010)

In experiments on rats with lateral TVIIIhemisection of the spinal cord and transplantation of ensheating olfactory cells, we studied structural changes at the lesion site and adjacent rostral and dorsal regions of the ...
Recombinant Plasmid DNA Construct Encoding Combination of vegf165 and bmp2 cDNAs Stimulates Osteogenesis and Angiogenesis In Vitro

Zhuravleva M.; Khaliullin M.; Masgutov R.; Deev R.; Rizvanov A. (2017)

© 2016, Springer Science+Business Media New York.Though normally bone regenerates well, non-union, delayed union, or defective bone formation can occur. Since impaired healing is often caused by local trophic disorders, ...
Regeneration of rat sciatic nerve using tubulation and allogeneic transplantation of adipose-derived mesenchymal stromal cells

Masgutov R.; Masgutova G.; Rogojin A.; Zhuravleva M.; Zakirova E.; Nigmetzyanova M.; Mukhametova L.; Shulman A.; Mukhamedshina Y.; Yafarova G.; Rizvanov A. (2016)

The effectiveness of application of biodegradable conduit (NeuraGen; INTEGRA, USA) in combination with adipose derived multipotent mesenchymal stem cells and fibrin sealant (Tissucol-Kit; Baxter AG, Austria) on posttraumatic ...
Stimulation of rat's sciatic nerve post-traumatic regeneration using plasmids expressing vascular endothelial growth factor and basic fibroblast growth factor

Masgutov R.; Salafutdinov I.; Bogov A.; Trofimova A.; Khannanova I.; Mullin R.; Islamov R.; Chelyshev Y.; Rizvanov A. (2011)

The development of effective treatments for patients with peripheral nerve injury is an urgent task of biomedicine. «Gold» standard in restoring the integrity of nerve conduits is auto-nerve transplantation in which a ...
Surgical Procedure for Extracting Pig Teeth for Isolation and Cultivation of Mesenchymal Stem Cells from Dental Pulp for Regenerative Therapy Applications

Masgutova G.; Mukhamedshina Y.; Sergeev M.; Shulman I.; Ogurtsov S.; Masgutov R.; Rizvanov A. (2017)

© 2016, Springer Science+Business Media New York.Mesenchymal stem cells (MSCs) are considered the most versatile cells for cell therapy—particularly for repair of injuries to the central nervous system. Recently, the use ...
The first clinical experience of direct gene therapy using VEGF and bFGF in treatment patients with critical lower limb ischemia

Plotnikov M.; Rizvanov A.; Masgutov R.; Mavlikeev M.; Salafutdinov I.; Gazizov I.; Romanova Y.; Shamsutdinova I.; Bogov A.; Maksimov A. (2012)

In this paper we present the clinical observation of successful treatment of distal form of peripheral artery disease of the lower extremity with symptoms of critical ischemia in a 60 years old patient. Intramuscular ...
Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report

Masgutov R.; Chekunov M.; Zhuravleva M.; Masgutova G.; Teplov O.; Salikhov R.; Galimov D.; Plakseichuk Y.; Rizvanov A. (2017)

© 2016, Springer Science+Business Media New York.This paper presents a clinical case of successful ulnar pseudarthrosis treatment using a gene-activated bone allograft containing VEGF (vascular endothelial growth factor) ...
Use of stromal vascular fraction of adipose tissue for treatment of femur pseudoarthtosis: Case report

Masgutov R.; Salihov R.; Plaseichuk Y.; Salafutdinov I.; Rizvanov A.; Bogov A. (2013)

The article presents a case report of successful treatment of pseudarthrosis of the femur with the use of autologous cells of the stromal vascular fraction (SVF) derived from adipose tissue. Autologous SVF cells mixed with ...

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Browsing by Author "Masgutov R."

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