Просмотр по теме "Butyrylcholinesterase"
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Boyko K.; Baymukhametov T.; Chesnokov Y.; Hons M.; Lushchekina S.; Konarev P.; Lipkin A.; Vasiliev A.; Masson P.; Popov V.; Kovalchuk M.
(2019)
© 2018 The Authors Human plasma butyrylcholinesterase (BChE) is an endogenous bioscavenger that hydrolyzes numerous medicamentous and poisonous esters and scavenges potent organophosphorus nerve agents. BChE is thus a ...
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Mukhametgalieva A.R.; Zueva I.V.; Aglyamova A.R.; Lushchekina S.V.; Masson P.
(2020)
© 2019 Elsevier B.V. A new spectrofluorimetric method more sensitive than the Ellman method was developed for determination of both acetylcholinesterase and butyrylcholinesterase activity and for kinetic analysis of these ...
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Terekhov S.; Smirnov I.; Bobik T.; Shamborant O.; Zenkova M.; Chernolovskaya E.; Gladkikh D.; Murashev A.; Dyachenko I.; Palikov V.; Palikova Y.; Knorre V.; Belogurov A.; Ponomarenko N.; Blackburn G.; Masson P.; Gabibov A.
(2015)
© 2015 Published by Elsevier B.V. Butyrylcholinesterase is a stoichiometric bioscavenger against poisoning by organophosphorus pesticides and nerve agents. The low level of expression and extremely rapid clearance of ...
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Неизвестный автор (2018)
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Butyrylcholinesterase (BChE) in human plasma is composed of four molecular forms: C1 (monomer); C2, covalent conjugate between BChE monomer and albumin; ...
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Lushchekina S.; Masson P.
(2018)
© 2018 Elsevier B.V. Catalytic bioscavengers are the second-generation bioscavengers. These biopharmaceuticals are intended to degrade toxic organophosphorus agents on the skin for decontamination or in the bloodstream for ...
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Terekhov S.; Smirnov I.; Shamborant O.; Bobik T.; Ilyushin D.; Murashev A.; Dyachenko I.; Palikov V.; Knorre V.; Belogurov A.; Ponomarenko N.; Kuzina E.; Genkin D.; Masson P.; Gabibov A.
(2015)
© 2015 Park-media, Ltd. Organophosphate toxins (OPs) are the most toxic low-molecular compounds. The extremely potent toxicity of OPs is determined by their specificity toward the nerve system. Human butyrylcholinesterase ...
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Smirnov I.; Vorobiev I.; Belogurov A.; Genkin D.; Deyev S.; Gabibov A.
(2015)
© Springer Science+Business Media New York 2015. All right reserved. Design of drug with prolonged therapeutic action is one of the rapid developing fields of modern medical science and required implementation of different ...
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Grigorenko B.; Novichkova D.; Lushchekina S.; Zueva I.; Schopfer L.; Nemukhin A.; Varfolomeev S.; Lockridge O.; Masson P.
(2019)
© 2019 Elsevier B.V. A computer-designed mutant of human butyrylcholinesterase (BChE), N322E/E325G, with a novel catalytic triad was made. The catalytic triad of the wild-type enzyme (S198·H438·E325) was replaced by ...
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Terekhov S.; Smirnov I.; Shamborant O.; Zenkova M.; Chernolovskaya E.; Gladkikh D.; Murashev A.; Dyachenko I.; Knorre V.; Belogurov A.; Ponomarenko N.; Deyev S.; Vlasov V.; Gabibov A.
(2014)
© 2014 Park-media, Ltd. Recombinant proteins represent a large sector of the biopharma market. Determination of the main elimination pathways raises the opportunities to significantly increase their half-lives in vivo. ...
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Mukhametgalieva A.R.; Kozlova A.S.; Akberova N.I.; Fattakhova A.N.
(2021)
Cholinesterase inhibitors have been the subject of many studies aimed at developing an effective treatment for various cognitive disorders. Therefore, studying cholinesterases and elucidating the mechanism of their interaction ...
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Terekhov S.; Smirnov I.; Stepanova A.; Bobik T.; Mokrushina Y.; Ponomarenko N.; Belogurov A.; Rubtsova M.; Kartseva O.; Gomzikova M.; Moskovtsev A.; Bukatin A.; Dubina M.; Kostryukova E.; Babenko V.; Vakhitova M.; Manolov A.; Malakhova M.; Kornienko M.; Tyakht A.; Vanyushkina A.; Ilina E.; Masson P.; Gabibov A.; Altman S.
(2017)
© 2017, National Academy of Sciences. All rights reserved.Ultrahigh-throughput screening (uHTS) techniques can identify unique functionality from millions of variants. To mimic the natural selection mechanisms that occur ...
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Неизвестный автор (2018)
© 2018 Lushchekina, Schopfer, Grigorenko, Nemukhin, Varfolomeev, Lockridge and Masson. Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OP poisoning causes major cholinergic syndrome. ...
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Lockridge O.; David E.; Schopfer L.; Masson P.; Brazzolotto X.; Nachon F.
(2018)
© 2018 Affinity chromatography on procainamide-Sepharose has been an important step in the purification of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) since its introduction in 1978. The procainamide ...
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Zlobin A.; Mokrushina Y.; Terekhov S.; Zalevsky A.; Bobik T.; Stepanova A.; Aliseychik M.; Kartseva O.; Panteleev S.; Golovin A.; Belogurov A.; Gabibov A.; Smirnov I.
(2018)
© 2018 Zlobin, Mokrushina, Terekhov, Zalevsky, Bobik, Stepanova, Aliseychik, Kartseva, Panteleev, Golovin, Belogurov, Gabibov and Smirnov. Butyrylcholinesterase (BChE) is considered as an efficient stoichiometric antidote ...
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Kharlamova A.; Lushchekina S.; Petrov K.; Kots E.; Nachon F.; Villard-Wandhammer M.; Zueva I.; Krejci E.; Reznik V.; Zobov V.; Nikolsky E.; Masson P.
(2016)
© 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, ...
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Masson P.; Lushchekina S.
(2016)
© 2016 Elsevier Inc. All rights reserved. Slow-binding inhibition (SBI) of enzymes is characterized by slow establishment of enzyme-inhibitor equilibrium. Cholinesterases (ChEs) display slow onset of inhibition with certain ...
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Schopfer L.; Delacour H.; Masson P.; Leroy J.; Krejci E.; Lockridge O.
(2017)
© 2017 by the authors. Licensee MDPI. Humans with the C5 genetic variant of butyrylcholinesterase (BChE) have 30–200% higher plasma BChE activity, low body weight, and shorter duration of action of the muscle relaxant ...
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Novichkova D.; Lushchekina S.; Dym O.; Masson P.; Silman I.; Sussman J.
(2019)
© 2019 Elsevier B.V. The crystal structures of truncated forms of cholinesterases provide good models for assessing the role of non-covalent interactions in dimer assembly in the absence of cross-linking disulfide bonds. ...
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Mukhametgalieva A.; Aglyamova A.; Lushchekina S.; Goličnik M.; Masson P.
(2019)
© 2019 Elsevier B.V. Competing substrate kinetic analysis of human butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) from the time-course of enzyme-catalyzed substrate hydrolysis, using spectrophotometric assays ...