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Browsing by Author "Lockridge O."

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Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium

Delacour H.; Lushchekina S.; Mabboux I.; Ceppa F.; Masson P.; Schopfer L.; Lockridge O. (2014)

© 2014 Elsevier Inc. All rights reserved. Butyrylcholinesterase deficiency is characterized by prolonged apnea after the use of muscle relaxants (suxamethonium or mivarcurium) in patients who have mutations in the BCHE ...
Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko B.; Novichkova D.; Lushchekina S.; Zueva I.; Schopfer L.; Nemukhin A.; Varfolomeev S.; Lockridge O.; Masson P. (2019)

© 2019 Elsevier B.V. A computer-designed mutant of human butyrylcholinesterase (BChE), N322E/E325G, with a novel catalytic triad was made. The catalytic triad of the wild-type enzyme (S198·H438·E325) was replaced by ...
Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins

Varfolomeev S.; Lushchekina S.; Nemukhin A.; Kulakova A.; Kots E.; Makhaeva G.; Delacour H.; Lockridge O.; Masson P. (2016)

© 2016, Springer Science+Business Media New York.The nature of individual sensitivity to drugs associated with molecular polymorphism of human enzymes is discussed. The influence of molecular polymorphism on the activity ...
Purification of recombinant human butyrylcholinesterase on Hupresin®

Lockridge O.; David E.; Schopfer L.; Masson P.; Brazzolotto X.; Nachon F. (2018)

© 2018 Affinity chromatography on procainamide-Sepharose has been an important step in the purification of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) since its introduction in 1978. The procainamide ...
The C5 variant of the butyrylcholinesterase tetramer includes a noncovalently bound 60 kDa lamellipodin fragment

Schopfer L.; Delacour H.; Masson P.; Leroy J.; Krejci E.; Lockridge O. (2017)

© 2017 by the authors. Licensee MDPI. Humans with the C5 genetic variant of butyrylcholinesterase (BChE) have 30–200% higher plasma BChE activity, low body weight, and shorter duration of action of the muscle relaxant ...

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Browsing by Author "Lockridge O."

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