Contractile responses of murine hearts subjected to different modes of motor activity to traumatic brain injury

Abstract

For the first time ever, this research studied the response of stroke volume in animals to various modes of motor activity after a traumatic brain injury. The study showed a pronounced decrease in stroke volume (SV) the first day after modeling an open craniocerebral injury in rats of all age groups. At the same time, the smallest SV response to brain injury was observed in immature animals. After modeling a traumatic brain injury, it was found that the implementation of systematic dynamic exercises by animals of pre-senile agedoes not contribute to increase SV; a significant increase in SV after a traumatic brain injury is observed only in immature animals. It was revealed that limiting physical activity and the performance of isometric exercises after a traumatic brain injury restrain a natural increase in SV in immature rat pups and decrease SV in sexually mature and pre-senile animals.