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Просмотр Научные публикации в Scopus по автору "Tutwiler V."

Просмотр Научные публикации в Scopus по автору "Tutwiler V."

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  • Activated Monocytes Enhance Platelet-Driven Contraction of Blood Clots via Tissue Factor Expression 
    Peshkova A.; Le Minh G.; Tutwiler V.; Andrianova I.; Weisel J.; Litvinov R. (2017)
    © 2017 The Author(s). Platelet-driven reduction in blood clot volume (clot contraction or retraction) has been implicated to play a role in hemostasis and thrombosis. Although these processes are often linked with inflammation, ...
  • Blood clot contraction differentially modulates internal and external fibrinolysis 
    Tutwiler V.; Peshkova A.; Le Minh G.; Zaitsev S.; Litvinov R.; Cines D.; Weisel J. (2019)
    © 2018 International Society on Thrombosis and Haemostasis Essentials Clot contraction influences the rate of fibrinolysis in vitro. Internal fibrinolysis is enhanced ∼2-fold in contracted vs. uncontracted blood clots. ...
  • Contraction of blood clots is impaired in acute ischemic stroke 
    Tutwiler V.; Peshkova A.; Andrianova I.; Khasanova D.; Weisel J.; Litvinov R. (2017)
    © 2016 American Heart Association, Inc.Objective - Obstructive thrombi or thrombotic emboli are the pathogenic basis of ischemic stroke. In vitro blood clots and in vivo thrombi can undergo platelet-driven contraction ...
  • Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood 
    Tutwiler V.; Litvinov R.; Lozhkin A.; Peshkova A.; Lebedeva T.; Ataullakhanov F.; Spiller K.; Cines D.; Weisel J. (2016)
    © 2016 by The American Society of Hematology. Platelet-driven blood clot contraction (retraction) is thought to promote wound closure and secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, ...
  • Molecular packing structure of fibrin fibers resolved by X-ray scattering and molecular modeling 
    Jansen K.A.; Zhmurov A.; Vos B.E.; Portale G.; Hermida-Merino D.; Litvinov R.I.; Tutwiler V.; Kurniawan N.A.; Bras W.; Weisel J.W.; Barsegov V.; Koenderink G.H. (2020)
    © The Royal Society of Chemistry. Fibrin is the major extracellular component of blood clots and a proteinaceous hydrogel used as a versatile biomaterial. Fibrin forms branched networks built of laterally associated ...
  • Pathologically stiff erythrocytes impede contraction of blood clots 
    Tutwiler V.; Litvinov R.I.; Protopopova A.; Nagaswami C.; Villa C.; Woods E.; Abdulmalik O.; Siegel D.L.; Russell J.E.; Muzykantov V.R.; Lam W.A.; Myers D.R.; Weisel J.W. (2021)
    Background: Blood clot contraction, volume shrinkage of the clot, is driven by platelet contraction and accompanied by compaction of the erythrocytes and their gradual shape change from biconcave to polyhedral, with the ...
  • Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia 
    Tutwiler V.; Madeeva D.; Ahn H.; Andrianova I.; Hayes V.; Zheng X.; Cines D.; McKenzie S.; Poncz M.; Rauova L. (2016)
    © 2016 by The American Society of Hematology. Heparin-induced thrombocytopenia (HIT) is characterized by a high incidence of thrombosis, unlike other antibody-mediated causes of thrombocytopenia. We have shown that monocytes ...
  • Rupture of blood clots: Mechanics and pathophysiology 
    Tutwiler V.; Singh J.; Litvinov R.I.; Bassani J.L.; Purohit P.K.; Weisel J.W. (2020)
    © 2020 The Authors. Fibrin is the three-dimensional mechanical scaffold of protective blood clots that stop bleeding and pathological thrombi that obstruct blood vessels. Fibrin must be mechanically tough to withstand ...
  • Shape changes of erythrocytes during blood clot contraction and the structure of polyhedrocytes 
    Tutwiler V.; Mukhitov A.; Peshkova A.; Le Minh G.; Khismatullin R.; Vicksman J.; Nagaswami C.; Litvinov R.; Weisel J. (2018)
    © 2018, The Author(s). Polyhedral erythrocytes, named polyhedrocytes, are formed in contracted blood clots and thrombi, as a result of compression by activated contractile platelets pulling on fibrin. This deformation was ...
  • Strength and deformability of fibrin clots: Biomechanics, thermodynamics, and mechanisms of rupture 
    Tutwiler V.; Maksudov F.; Litvinov R.I.; Weisel J.W.; Barsegov V. (2021)
    Fibrin is the major determinant of the mechanical stability and integrity of blood clots and thrombi. To explore the rupture of blood clots, emulating thrombus breakage, we stretched fibrin gels with single-edge cracks of ...

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