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Browsing Научные публикации в Scopus by Author "Kotov N."

Browsing Научные публикации в Scopus by Author "Kotov N."

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  • Valeyev N.; Downing A.; Skorinkin A.; Campbell I.; Kotov N. (2006)
    Cell migration has long been studied by a variety of techniques and many proteins have been implicated in its regulation. Integrins, key proteins that link the cell to the extracellular matrix, are central to adhesion ...
  • Kotov N.; Baker R.; Dawidov D.; Platov K.; Valeyev N.; Skorinkin A.; Maini P. (2007)
    It is known that most enzyme-facilitated reactions are highly temperature dependent processes. In general, the temperature coefficient, Q10, of a simple reaction reaches 2.0-3.0. Nevertheless, some enzyme-controlled processes ...
  • Valeyev N.; Hundhausen C.; Umezawa Y.; Kotov N.; Williams G.; Clop A.; Ainali C.; Ouzounis C.; Tsoka S.; Nestle F. (2010)
    Inflammation is characterized by altered cytokine levels produced by cell populations in a highly interdependent manner. To elucidate the mechanism of an inflammatory reaction, we have developed a mathematical model for ...
  • Sadreev I.; Chen M.; Welsh G.; Umezawa Y.; Kotov N.; Valeyev N. (2014)
    © 2014 Sadreev et al. Phosphorylation is a fundamental biochemical reaction that modulates protein activity in cells. While a single phosphorylation event is relatively easy to understand, multisite phosphorylation requires ...
  • Kotov N.; Bates D.; Gizatullina A.; Gilaziev B.; Khairullin R.; Chen M.; Drozdov I.; Umezawa Y.; Hundhausen C.; Aleksandrov A.; Yan X.; Spurgeon S.; Smales C.; Valeyev N. (2011)
    Background: Ciliary dysfunction leads to a number of human pathologies, including primary ciliary dyskinesia, nephronophthisis, situs inversus pathology or infertility. The mechanism of cilia beating regulation is complex ...
  • Valeyev N.; Kim J.; Heslop-Harrison J.; Postlethwaite I.; Kotov N.; Bates D. (2009)
    Under conditions of starvation, Dictyostelium cells begin a programme of development during which they aggregate to form a multicellular structure by chemotaxis, guided by propagating waves of cyclic AMP that are relayed ...
  • Valeyev N.; Heslop-Harrison P.; Postlethwaite I.; Gizatullina A.; Kotov N.; Bates D. (2009)
    Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate ...
  • Pelaz B.; Alexiou C.; Alvarez-Puebla R.; Alves F.; Andrews A.; Ashraf S.; Balogh L.; Ballerini L.; Bestetti A.; Brendel C.; Bosi S.; Carril M.; Chan W.; Chen C.; Chen X.; Cheng Z.; Cui D.; Du J.; Dullin C.; Escudero A.; Feliu N.; Gao M.; George M.; Gogotsi Y.; Grünweller A.; Gu Z.; Halas N.; Hampp N.; Hartmann R.; Hersam M.; Hunziker P.; Jian J.; Jiang X.; Jungebluth P.; Kadhiresan P.; Kataoka K.; Khademhosseini A.; Kopeček J.; Kotov N.; Krug H.; Lee D.; Lehr C.; Leong K.; Liang X.; Ling Lim M.; Liz-Marzán L.; Ma X.; Macchiarini P.; Meng H.; Möhwald H.; Mulvaney P.; Nel A.; Nie S.; Nordlander P.; Okano T.; Oliveira J.; Park T.; Penner R.; Prato M.; Puntes V.; Rotello V.; Samarakoon A.; Schaak R.; Shen Y.; Sjöqvist S.; Skirtach A.; Soliman M.; Stevens M.; Sung H.; Tang B.; Tietze R.; Udugama B.; VanEpps J.; Weil T.; Weiss P. (2017)
    © 2017 American Chemical Society.The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a ...
  • Valeyev N.; Bates D.; Heslop-Harrison P.; Postlethwaite I.; Kotov N. (2008)
    Background: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it ...
  • Bazanovas A.; Evstifeev A.; Khaiboullina S.; Sadreev I.; Skorinkin A.; Kotov N. (2015)
    © 2015 The Authors. Human erythrocytes are highly specialized enucleate cells that are involved in providing efficient gas transport. Erythrocytes have been extensively studied both experimentally and by mathematical ...
  • Zakharov A.; Petrov A.; Kotov N.; Zefirov A. (2012)
    Under the condition of microelectrode recording and fluorescence microscopy with dye FM 1-43 the research of exo-/endocytosis of synaptic vesicles in motor nerve terminals (NT) of frog cutaneous pectoris and white mice ...
  • Litvin V.; Samigullin D.; Kotov N. (1999)
    The escape reaction in Paramecium caudatum has been investigated experimentally. A model of molecular system controlling cilia in cells during this reaction is described.
  • Salakhieva D.; Sadreev I.; Chen M.; Umezawa Y.; Evstifeev A.; Welsh G.; Kotov N. (2016)
    © 2016 Salakhieva et al.Background: Second messengers, such as calcium, regulate the activity of multisite binding proteins in a concentration-dependent manner. For example, calcium binding has been shown to induce ...
  • Kotov N.; Miroshnikov V.; Yudin I. (1992)
    A physical approach is proposed to the description of the mechanism of motion of cilia based on the assumption of the importance of the hydrodynamic interactions within the cilium and the mechanism of synchronization of ...
  • Kotov N.; Volchenko A.; Davydov D.; Kostyleva E.; Sadykov I.; Platov K. (2000)
    A systemic study of the mechanisms of motor activity of paramecium was carried out. The movements of paramecium responding to various influences were photographed. The analysis of the data revealed the time dependences of ...
  • Kotov N.; Volchenko A.; Davydov D.; Kostyleva E.; Sadykov I.; Platov K. (2000)
    A systemic study of the mechanisms of motor activity of paramecium was carried out. The movements of paramecium responding to various influences were photographed. The analysis of the data revealed the time dependences of ...
  • Valeyev N.; Heslop-Harrison P.; Postlethwaite I.; Kotov N.; Bates D. (2007)
    Protein-protein or protein-ion interactions with multisite proteins are essential to the regulation of intracellular and extracellular events. There is, however, limited understanding of how ligand-multisite protein ...
  • Davydov D.; Platov K.; Kotov N. (2000)
    A mathematical model of the dynamic behavior of phosphorylase kinase was devised. Based on the results obtained, the function of this protein is discussed. It is suggested that phosphorylase kinase doses in a cAMP-dependent ...
  • Davydov D.; Platov K.; Kotov N. (2000)
    A mathematical model of the dynamic behavior of phosphorylase kinase was devised. Based on the results obtained, the function of this protein is discussed. It is suggested that phosphorylase kinase doses in a cAMP-dependent ...
  • Valeyev N.; Bates D.; Umezawa Y.; Gizatullina A.; Kotov N. (2010)
    Systems Biology approaches to drug discovery largely focus on the increasing understanding of intracellular and cellular circuits, by computational representation of a molecular system followed by parameter validation ...

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