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Biological Activity of Bicyclic Monoterpene Alcohols

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dc.contributor.author Nikitina L.E.
dc.contributor.author Lisovskaya S.A.
dc.contributor.author Startseva V.A.
dc.contributor.author Frolova L.L.
dc.contributor.author Kutchin A.V.
dc.contributor.author Shevchenko O.G.
dc.contributor.author Ostolopovskaya O.V.
dc.contributor.author Pavelyev R.S.
dc.contributor.author Khelkhal M.A.
dc.contributor.author Gilfanov I.R.
dc.contributor.author Fedyunina I.V.
dc.contributor.author Khaliullin R.R.
dc.contributor.author Akhverdiev R.F.
dc.contributor.author Gerasimov A.V.
dc.contributor.author Abzaldinova E.V.
dc.contributor.author Izmailov A.G.
dc.date.accessioned 2022-02-09T20:47:19Z
dc.date.available 2022-02-09T20:47:19Z
dc.date.issued 2021
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/170292
dc.description.abstract The present paper aims to study the biological properties of a series of bicyclic monoterpene alcohols. Firstly, we tested the obtained compounds for fungicidal activity against clinical and reference strains of microscopic fungi. Next, we determined the minimum inhibitory concentration of these compounds comparing to other drugs widely used in practical medicine (fluconazole, terbinafine). At this stage, we found that (−)-myrtenol (47 MIC and 23.5 μg/ml) exhibits the most promising activity against filamentous and yeast fungi, respectively. Then, we have studied the membrane-protective and antioxidant activities of the obtained compounds and found out that (−)-cis-verbenol and (−)-myrtenol exhibit the highest activity on the model of erythrocytes oxidative hemolysis. Interestingly, among all the studied bicyclic monoterpene alcohols, the alcohols of the pinane series have been found to be the most promising. The obtained results from the present study suggest that (−)-myrtenol would be a leading compound for further studies in terms of possible practical application.
dc.relation.ispartofseries BioNanoScience
dc.subject Antifungal activity
dc.subject Antioxidant activity
dc.subject Bicyclic monoterpene alcohols
dc.subject Oxidative hemolysis
dc.title Biological Activity of Bicyclic Monoterpene Alcohols
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 11
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 970
dc.source.id SCOPUS21911630-2021-11-4-SID85116991336


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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