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Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation

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dc.contributor.author Siddiqui A.M.
dc.contributor.author Islam R.
dc.contributor.author Cuellar C.A.
dc.contributor.author Silvernail J.L.
dc.contributor.author Knudsen B.
dc.contributor.author Curley D.E.
dc.contributor.author Strickland T.
dc.contributor.author Manske E.
dc.contributor.author Suwan P.T.
dc.contributor.author Latypov T.
dc.contributor.author Akhmetov N.
dc.contributor.author Zhang S.
dc.contributor.author Summer P.
dc.contributor.author Nesbitt J.J.
dc.contributor.author Chen B.K.
dc.contributor.author Grahn P.J.
dc.contributor.author Madigan N.N.
dc.contributor.author Yaszemski M.J.
dc.contributor.author Windebank A.J.
dc.contributor.author Lavrov I.A.
dc.date.accessioned 2022-02-09T20:45:31Z
dc.date.available 2022-02-09T20:45:31Z
dc.date.issued 2021
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/170077
dc.description.abstract Here, we report the effect of newly regenerated axons via scaffolds on reorganization of spinal circuitry and restoration of motor functions with epidural electrical stimulation (EES). Motor recovery was evaluated for 7 weeks after spinal transection and following implantation with scaffolds seeded with neurotrophin producing Schwann cell and with rapamycin microspheres. Combined treatment with scaffolds and EES-enabled stepping led to functional improvement compared to groups with scaffold or EES, although, the number of axons across scaffolds was not different between groups. Re-transection through the scaffold at week 6 reduced EES-enabled stepping, still demonstrating better performance compared to the other groups. Greater synaptic reorganization in the presence of regenerated axons was found in group with combined therapy. These findings suggest that newly regenerated axons through cell-containing scaffolds with EES-enabled motor training reorganize the sub-lesional circuitry improving motor recovery, demonstrating that neuroregenerative and neuromodulatory therapies cumulatively enhancing motor function after complete SCI.
dc.title Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 6
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2021-6-1-SID85117737280


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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