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Acquisition and spread of antimicrobial resistance: a tet(X) case study

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dc.contributor.author Aminov R.
dc.date.accessioned 2022-02-09T20:38:35Z
dc.date.available 2022-02-09T20:38:35Z
dc.date.issued 2021
dc.identifier.issn 1661-6596
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/169520
dc.description.abstract Understanding the mechanisms leading to the rise and dissemination of antimicrobial resistance (AMR) is crucially important for the preservation of power of antimicrobials and controlling infectious diseases. Measures to monitor and detect AMR, however, have been significantly delayed and introduced much later after the beginning of industrial production and consumption of antimicrobials. However, monitoring and detection of AMR is largely focused on bacterial pathogens, thus missing multiple key events which take place before the emergence and spread of AMR among the pathogens. In this regard, careful analysis of AMR development towards recently introduced antimicrobials may serve as a valuable example for the better understanding of mechanisms driving AMR evolution. Here, the example of evolution of tet(X), which confers resistance to the next-generation tetracyclines, is summarised and discussed. Initial mechanisms of resistance to these antimicrobials among pathogens were mostly via chromosomal mutations leading to the overexpression of efflux pumps. High-level resistance was achieved only after the acquisition of flavin-dependent monooxygenase-encoding genes from the environmental microbiota. These genes confer resistance to all tetracyclines, including the next-generation tetracyclines, and thus were termed tet(X). ISCR2 and IS26, as well as a variety of conjugative and mobilizable plasmids of different incompatibility groups, played an essential role in the acquisition of tet(X) genes from natural reservoirs and in further dissemination among bacterial commensals and pathogens. This process, which took place within the last decade, demonstrates how rapidly AMR evolution may progress, taking away some drugs of last resort from our arsenal.
dc.relation.ispartofseries International Journal of Molecular Sciences
dc.subject Antimicrobial resistance
dc.subject Horizontal gene transfer
dc.subject Mobile genetic elements
dc.subject Natural reservoirs
dc.subject Next-generation tetracyclines
dc.subject Tetracyclines
dc.title Acquisition and spread of antimicrobial resistance: a tet(X) case study
dc.type Review
dc.relation.ispartofseries-issue 8
dc.relation.ispartofseries-volume 22
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS16616596-2021-22-8-SID85103824949


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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