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Sequence does not matter: The biomedical applications of dna-based coatings and cores

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dc.contributor.author Batasheva S.
dc.contributor.author Fakhrullin R.
dc.date.accessioned 2022-02-09T20:38:32Z
dc.date.available 2022-02-09T20:38:32Z
dc.date.issued 2021
dc.identifier.issn 1661-6596
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/169515
dc.description.abstract Biomedical applications of DNA are diverse but are usually associated with specific recognition of target nucleotide sequences or proteins and with gene delivery for therapeutic or biotechnological purposes. However, other aspects of DNA functionalities, like its nontoxicity, biodegradability, polyelectrolyte nature, stability, thermo-responsivity and charge transfer ability that are rather independent of its sequence, have recently become highly appreciated in material science and biomedicine. Whereas the latest achievements in structural DNA nanotechnology associated with DNA sequence recognition and Watson–Crick base pairing between complementary nucleotides are regularly reviewed, the recent uses of DNA as a raw material in biomedicine have not been summarized. This review paper describes the main biomedical applications of DNA that do not involve any synthesis or extraction of oligo-or polynucleotides with specified sequences. These sequence-independent applications currently include some types of drug delivery systems, biocompatible coatings, fire retardant and antimicrobial coatings and biosensors. The reinforcement of DNA properties by DNA complexation with nanoparticles is also described as a field of further research.
dc.relation.ispartofseries International Journal of Molecular Sciences
dc.subject DNA-clay composites
dc.subject Drug delivery
dc.subject Flame retardancy
dc.subject Implant
dc.subject Layer-by-layer assembly
dc.subject Polyelectrolyte multilayers
dc.subject Tissue scaffold
dc.title Sequence does not matter: The biomedical applications of dna-based coatings and cores
dc.type Review
dc.relation.ispartofseries-issue 23
dc.relation.ispartofseries-volume 22
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS16616596-2021-22-23-SID85119917630


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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