Электронный архив

The Effect of Divalent Ions on the Structure of Bilayers in the Dimyristoylphosphatidylcholine Vesicles

Показать сокращенную информацию

dc.contributor.author Kurakin S.A.
dc.contributor.author Ermakova E.V.
dc.contributor.author Ivankov A.I.
dc.contributor.author Smerdova S.G.
dc.contributor.author Kučerka N.
dc.date.accessioned 2022-02-09T20:35:13Z
dc.date.available 2022-02-09T20:35:13Z
dc.date.issued 2021
dc.identifier.issn 1027-4510
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/169214
dc.description.abstract Abstract: We have studied changes in the structural parameters of 1,2-dimyristoyl-sn-3-phosphocholine (DMPC) unilamellar vesicles at a concentration series 0–30 mM of divalent metal cations Ca2+, Mg2+, and Co2+ by means of small-angle neutron scattering (SANS). The membrane structural parameters (thickness and area per lipid) were obtained at different concentrations of cations in the gel and fluid phases of membrane. Both Ca2+ and Mg2+ ions at the concentrations of 0–1 mM increase the membrane thickness by 1.9 Å and 2.9 Å in the fluid and gel phase, respectively. In the concentration range of 1–30 mM, either a weak tendency to a thickness decrease of ~ 1 Å is observed, or the thickness does not change at all. In the case of Co2+ ions, all changes are extremely weak. We advocate a model of electrostatic interactions for these systems that encompasses the formation of ion bridges between lipid headgroups. Using the Langmuir adsorption isotherm we estimate the fraction of Ca2+ ions bound to the DMPC membrane. The developed model is of an interest to the future studies of membrane interactions with various charged peptides, such as those from the amyloid-β family.
dc.relation.ispartofseries Journal of Surface Investigation
dc.subject area per lipid
dc.subject lipid membranes
dc.subject membrane thickness
dc.subject metal ions
dc.subject small-angle neutron scattering
dc.subject thermodynamic state
dc.title The Effect of Divalent Ions on the Structure of Bilayers in the Dimyristoylphosphatidylcholine Vesicles
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 15
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 211
dc.source.id SCOPUS10274510-2021-15-2-SID85099158238


Файлы в этом документе

Данный элемент включен в следующие коллекции

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Показать сокращенную информацию

Поиск в электронном архиве


Расширенный поиск

Просмотр

Моя учетная запись

Статистика