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The Effect of Divalent Ions on the Structure of Bilayers in the Dimyristoylphosphatidylcholine Vesicles

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dc.contributor.author Kurakin S.A.
dc.contributor.author Ermakova E.V.
dc.contributor.author Ivankov A.I.
dc.contributor.author Smerdova S.G.
dc.contributor.author Kučerka N.
dc.date.accessioned 2022-02-09T20:35:13Z
dc.date.available 2022-02-09T20:35:13Z
dc.date.issued 2021
dc.identifier.issn 1027-4510
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/169214
dc.description.abstract Abstract: We have studied changes in the structural parameters of 1,2-dimyristoyl-sn-3-phosphocholine (DMPC) unilamellar vesicles at a concentration series 0–30 mM of divalent metal cations Ca2+, Mg2+, and Co2+ by means of small-angle neutron scattering (SANS). The membrane structural parameters (thickness and area per lipid) were obtained at different concentrations of cations in the gel and fluid phases of membrane. Both Ca2+ and Mg2+ ions at the concentrations of 0–1 mM increase the membrane thickness by 1.9 Å and 2.9 Å in the fluid and gel phase, respectively. In the concentration range of 1–30 mM, either a weak tendency to a thickness decrease of ~ 1 Å is observed, or the thickness does not change at all. In the case of Co2+ ions, all changes are extremely weak. We advocate a model of electrostatic interactions for these systems that encompasses the formation of ion bridges between lipid headgroups. Using the Langmuir adsorption isotherm we estimate the fraction of Ca2+ ions bound to the DMPC membrane. The developed model is of an interest to the future studies of membrane interactions with various charged peptides, such as those from the amyloid-β family.
dc.relation.ispartofseries Journal of Surface Investigation
dc.subject area per lipid
dc.subject lipid membranes
dc.subject membrane thickness
dc.subject metal ions
dc.subject small-angle neutron scattering
dc.subject thermodynamic state
dc.title The Effect of Divalent Ions on the Structure of Bilayers in the Dimyristoylphosphatidylcholine Vesicles
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 15
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 211
dc.source.id SCOPUS10274510-2021-15-2-SID85099158238


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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