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dc.contributor.author | Stepanov A. | |
dc.contributor.author | Fedorenko S. | |
dc.contributor.author | Mendes R. | |
dc.contributor.author | Rümmeli M. | |
dc.contributor.author | Giebeler L. | |
dc.contributor.author | Weise B. | |
dc.contributor.author | Gemming T. | |
dc.contributor.author | Dutz S. | |
dc.contributor.author | Zahn D. | |
dc.contributor.author | Ismaev I. | |
dc.contributor.author | Amirov R. | |
dc.contributor.author | Kholin K. | |
dc.contributor.author | Voloshina A. | |
dc.contributor.author | Sapunova A. | |
dc.contributor.author | Solovieva S. | |
dc.contributor.author | Mustafina A. | |
dc.date.accessioned | 2022-02-09T20:34:58Z | |
dc.date.available | 2022-02-09T20:34:58Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0974-3626 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/169183 | |
dc.description.abstract | The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8±2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1±14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM−1 s−1, respectively) at 1.5 T and 25 °C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core-shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia. Graphical abstract: [Figure not available: see fulltext.] | |
dc.relation.ispartofseries | Journal of Chemical Sciences | |
dc.subject | Gd complexes | |
dc.subject | Hyperthermia | |
dc.subject | Iron-oxide nanoparticles | |
dc.subject | Magnetic resonance imaging | |
dc.title | T<inf>2</inf>- and T<inf>1</inf> relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 2 | |
dc.relation.ispartofseries-volume | 133 | |
dc.collection | Публикации сотрудников КФУ | |
dc.source.id | SCOPUS09743626-2021-133-2-SID85104715594 |