dc.contributor.author |
Stepanov A. |
|
dc.contributor.author |
Fedorenko S. |
|
dc.contributor.author |
Mendes R. |
|
dc.contributor.author |
Rümmeli M. |
|
dc.contributor.author |
Giebeler L. |
|
dc.contributor.author |
Weise B. |
|
dc.contributor.author |
Gemming T. |
|
dc.contributor.author |
Dutz S. |
|
dc.contributor.author |
Zahn D. |
|
dc.contributor.author |
Ismaev I. |
|
dc.contributor.author |
Amirov R. |
|
dc.contributor.author |
Kholin K. |
|
dc.contributor.author |
Voloshina A. |
|
dc.contributor.author |
Sapunova A. |
|
dc.contributor.author |
Solovieva S. |
|
dc.contributor.author |
Mustafina A. |
|
dc.date.accessioned |
2022-02-09T20:34:58Z |
|
dc.date.available |
2022-02-09T20:34:58Z |
|
dc.date.issued |
2021 |
|
dc.identifier.issn |
0974-3626 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/169183 |
|
dc.description.abstract |
The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8±2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1±14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM−1 s−1, respectively) at 1.5 T and 25 °C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core-shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia. Graphical abstract: [Figure not available: see fulltext.] |
|
dc.relation.ispartofseries |
Journal of Chemical Sciences |
|
dc.subject |
Gd complexes |
|
dc.subject |
Hyperthermia |
|
dc.subject |
Iron-oxide nanoparticles |
|
dc.subject |
Magnetic resonance imaging |
|
dc.title |
T<inf>2</inf>- and T<inf>1</inf> relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
2 |
|
dc.relation.ispartofseries-volume |
133 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.source.id |
SCOPUS09743626-2021-133-2-SID85104715594 |
|