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dc.contributor.author | Kabdesh I.M. | |
dc.contributor.author | Arkhipova S.S. | |
dc.contributor.author | Mukhamedshina Y.O. | |
dc.contributor.author | James V. | |
dc.contributor.author | Rizvanov A.A. | |
dc.contributor.author | Chelyshev Y.A. | |
dc.date.accessioned | 2022-02-09T20:33:50Z | |
dc.date.available | 2022-02-09T20:33:50Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0306-4522 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/169040 | |
dc.description.abstract | Emerging evidence supports an increased role for NG2/CSPG4-expressing cells in the process of neuroregeneration and synaptic plasticity, due to the increased production of multifunctional chondroitin sulfate proteoglycan (NG2/CSPG4). However, the response of NG2/CSPG4-expressing cells in spinal cord injury (SCI) remains to be elcudiated. Expression and distribution of NG2/CSPG4-expressing cells were studied by immunoelectron microscopy in the ventral horns (VH) of an intact and injured rat spinal cord. In the intact spinal cord, NG2/CSPG4 expression was detected on the cell membrane and in the cytoplasm of NG2 glia and was absent in neurons. Large amounts of NG2/CSPG4 were found on myelin membranes. The ability of intact astrocytes to produce NG2/CSPG4 was shown, although to a lesser extent than oligodendrocytes and NG2 glia. At 7 days after SCI at the Th8 level in the reactive glial zone of VH, the expression of NG2/CSPG4 sharply increased in NG2 glia at a distance of 3–5 mm and in reactive astrocytes were observed at all investigated distances caudally from the epicenter of injury. The obtained results indicate the presence of NG2/CSPG4-positive astrocytes in the intact spinal cord, and in the case of damage, an increase in the ability of reactive astrocytes to produce NG2/CSPG4. SCI leads to increased expression of NG2/CSPG4 by NG2 glia in the early stages after injury, which decreases with distance from the epicenter of the injury, as well as at later stages. | |
dc.relation.ispartofseries | Neuroscience | |
dc.subject | ALDH1L1 | |
dc.subject | Astrocytes | |
dc.subject | electron microscopy | |
dc.subject | NG2 glia | |
dc.subject | NG2/CSPG4 | |
dc.subject | spinal cord injury | |
dc.title | The Function of NG2/CSPG4-expressing Cells in the Rat Spinal Cord Injury: An Immunoelectron Microscopy Study | |
dc.type | Article | |
dc.relation.ispartofseries-volume | 467 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 142 | |
dc.source.id | SCOPUS03064522-2021-467-SID85107986593 |